Effects of TJN-505, an aconitine-like compound, on aconitine-induced arrhythmias and membrane ionic currents
نویسندگان
چکیده
منابع مشابه
Aconitine-induced cardiac arrhythmia.
Renewed interest in the pharmacological action of aconitine has followed the work of Sherf (1947), Prinzmetal et al. (1950 and 1951), and Brown and Acheson (1952). Its use in experimental medicine produces stimulus formation in the dog's heart with auricular tachycardia and in certain circumstances ventricular tachycardia and fibrillation: it has become a useful tool in the hands of the researc...
متن کاملRole of the Alternans of Action Potential Duration and Aconitine-Induced Arrhythmias in Isolated Rabbit Hearts
Under conditions of Na(+) channel hyperactivation with aconitine, the changes in action potential duration (APD) and the restitution characteristics have not been well defined in the context of aconitine-induced arrhythmogenesis. Optical mapping of voltage using RH237 was performed with eight extracted rabbit hearts that were perfused using the Langendorff system. The characteristics of APD res...
متن کاملAconitine - Induced Auricular Arrhythmias and Their Relation to Circus - Movement Flutter By BARBARA
Certain characteristics of aconitine-induced auricular arrhythmias in dogs and the responses of aconitine-induced flutter to various experimental procedures and to drugs are described. In certain experiments there was evidence that a secondary flutter mechanism had developed which, in some instances, resembled flutter of circus-movement origin. When aconitine-induced and circus-movement flutter...
متن کاملAconitine-induced auricular arrhythmias and their relation to circus-movement flutter.
Certain characteristics of aconitine-induced auricular arrhythmias in dogs and the responses of aconitine-induced flutter to various experimental procedures and to drugs are described. In certain experiments there was evidence that a secondary flutter mechanism had developed which, in some instances, resembled flutter of circus-movement origin. When aconitine-induced and circus-movement flutter...
متن کاملAconitine-induced modification of single sodium channels in neuroblastoma cell membrane.
Aconitine-modified sodium channels in the neuroblastoma cell membrane were investigated with patch-clamp technique in outside-out configuration. When aconitine (0.1 mmol/l) was present in the pipette solution two types of modified single sodium channels were observed. The first type showed openings with normal amplitude (slope conductance 15.5 pS) and bursting behaviour. The second type of modi...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1997
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)45466-8